KOLKATA — Can anti-cancer drugs be delivered to patients through genetically modified fruits and vegetables? Yes, says acclaimed Indian American researcher Ananda Mohan Chakrabarty, terming genetically modified organisms the future of anti-cancer therapy and even preventive medicine.
“The opposition to GMOs would wane if people knew that genetically modified foods contain anti-cancer agents. They are opposing GMOs, because they know such products benefit only the makers. What if they (the GMOs) could serve as carriers of anti-cancer agents,” Chakrabarty said here Sept. 29 at the Bengal science lecture series organized by the West Bengal government’s science and technology department.
The University of Calcutta alumnus is a distinguished university professor in the department of microbiology and immunology in the University of Illinois and is currently working with bacterial proteins to treat and prevent cancer.
In collaboration with researchers in New Delhi, Japan, Mexico and Portugal, Chakrabarty is examining the prospects of genetically engineering plants so that they can manufacture the bacterial protein as part of their metabolism.
He and his colleagues isolated a bacterial protein, azurin, from Pseudomonas aeruginosa and showed that the protein, as well as its fragment, called peptide 28, were able to selectively kill cancer cells while not attacking healthy cells. It also had cancer preventive effects.
Similarly, the team also exhibited that the Laz protein produced by Neisseria meningitides (which causes meningitis), is toxic to brain tumor cells.
“In Mexico, for example, plant biotechnologist Miguel Gomez was able to express azurin in tomatoes. The plant extract was found to have the anti-cancer activity, and now they are trying to find out whether the plant extract can kill tumor cells in micea, so we will have some answers in the next two years,” said Chakrabarty.
“So young women in rural areas who can’t afford expensive treatments and know they have a history of cancer in their families could get the essential protein through plants as a preventive measure instead of getting their ovaries and breasts surgically removed,” he explained, highlighting how Hollywood actress Angelina Jolie did the latter.
Chakrabarty has been an advisor to governments and the United Nations, and received the Padma Shri from the Indian government in 2007 for his contributions to genetic engineering technology in 2007.
The bacteria engineered by Chakrabarti drew international attention when he applied for a patent — “the first U.S. patent for a GMO.”
He was initially denied the patent by the U.S. Patent Office, because it was thought that the patent code precluded patents on living organisms.
His landmark research has since paved the way for many patents on GMOs and other life forms.